Clinical Programs

Current Clinical Trial Publications & Abstracts:
"Good Manufacturing Practice-Compliant Expansion of Marrow-Derived Stem and Progenitor Cells for Cell Therapy"
-	M.H. Gastens, K. Goltry, W. Prohaska, D. Tschöpe, B. Stratmann, D. Lammers, S. Kirana, C. G?tting, K. Kleesiek
-	Cell Transplantation, Vol. 16(7): 685-696, 2007
"High Dose Stem and Progenitor Cell Therapy for Refractory Long Bone Non-Unions: Final Results of a Multi-Center Phase I/II Clinical Study"
-	M.L. Jimenez, T. Lyon, G. Nowinski, J. Balazsy, J.A. Goulet, J.M. Hock, T.A. Sferra
-	Orthopaedic Trauma Association 23rd Annual Meeting (OTA), 10/07
"Cellular Based Therapy for the Treatment of Osteonecrosis of the Femoral Head"
-	M.R. Kreke, J.A. Rowley, K.L. Goltry, R.L. Bartel
-	ARCO (Association Research Circulation Osseous) Annual Meeting, 10/07
"Stem Cell-Based Therapy for the Treatment of Femoral Head Necrosis - First Clinical Experience"
-	U. Nöth
-	2nd Congress of the German Society for Stem Cell Research, 10/07
"Autologous Tissue Repair Cells (TRCs) in the Treatment of Ischemia Induced Chronic Tissue Ulcers of Diabetic Foot Patients Without Option of Revascularization: Interim Results"
-	B. Stratmann
-	2nd Congress of the German Society for Stem Cell Research, 10/07
"Accessory Cells Enhance Osteogenic Potential of Bone Marrow Derived Mesenchymal Cells"
-	A. Pennington, J. Dennis, C. Parrish, J. Lee, K. Goltry
-	MSC2007 o Adult Mesenchymal Stem Cells in Regenerative Medicine, 8/07
"Clinical-Scale Expansion of a Mixed Population of Bone Marrow Derived Stem and Progenitor Cells for Potential Use in Bone Tissue Regeneration"
-	J.E. Dennis, K. Esterly, A. Awadallah, C.R. Parrish, G.M. Poynter, K.L. Goltry
-	Stem Cells, Published online 6/21/07, DOI: 10.1634/stemcells.2007-0204, http://www.StemCells.com
"Cell-Based Therapy for the Treatment of Femoral Head Necrosis" (Translated from: 'Zellbasierte Therapie der Femurkopfnekrose')
-	U. Nöth, J. Reichert, S. Reppenhagen, A. Steinert, L. Rackwitz, J. Eulert, J. Beckmann, M. Tingart
-	Der Orthopäde, Vol. 36(5): 466-471, 5/07
"Enhancing the Osteogenic Potential of Bone-Marrow Derived Progenitor Cells in Primary Culture"
-	K.L. Goltry, J.J. Lee, C.R. Parrish
-	28th Annual Meeting of the American Society for Bone & Mineral Research (ASBMR), 9/06
"Feasibility Clinical Trial: Early Results Show Healing of Recalcitrant Non-Union Fractures Using Autologous Tissue Repair Cells, a Bone Marrow-Derived Tissue Enriched for Adult Stem and Progenitor Cells"
-	M. Jimenez, T. Lyon, J. Balazsy, G. Nowinski, J. Goulet, S. Wolff, J. Block, T. Sferra, R.D. Armstrong, J. Douville, G. O'Brien, J.M. Hock
-	28th Annual Meeting of the American Society for Bone & Mineral Research (ASBMR), 9/06
"Efficient Tracking of the Fate of Human Bone Marrow Stem Cells for Bone Regeneration Using a Bone-Specific Promoter Driving GFP Within a Lentiviral Vector"
-	D. Yin, Z. Wang, Q. Gao, R. Sundaresan, C. Parrish, P.H. Krebsbach, A. Lichtler, D.W. Rowe, J.M. Hock, P. Liu
-	28th Annual Meeting of the American Society for Bone & Mineral Research (ASBMR), 9/06
"Adult Bone Marrow-Derived Cells Cultured by Single Pass Perfusion Technology Induce Bony Spine Fusion in Immunodeficient Rats"
-	K.M. Esterly, E. Frankenburg, S. Oyserman, R. Pavlic, C. Parrish, J. Kreider, J.M. Kreider, S. Goldstein
-	4th Annual Meeting of the International Society for Stem Cell Research (ISSCR), 6/06
"Regulation of the Cell Cycle During Ex Vivo Expansion of Bone Marrow-Derived Stem Cells for use in Autologous Cell Therapy"
-	K. Goltry, C. Parrish, B. Pavlic, J.M. Hock
-	4th Annual Meeting of the International Society for Stem Cell Research (ISSCR), 6/06
"Ex Vivo Expanded Osteoprogenitor Cells: Mixed vs Purified Cell Populations for Bone Regeneration"
-	M.R. Kreke, K.J. Whittlesey, J.J. Lee, G.M. Poynter, C. Parrish, A. Awadallah, J.E. Dennis, K.L. Goltry
-	4th Annual Meeting of the International Society for Stem Cell Research (ISSCR), 6/06
"Ex Vivo Expanded Bone Marrow-Derived Stem and Progenitor Cells Express a Cellular Composition and Molecular Profile with High Functionality for Tissue Repair in the Absence of Tissue Destructive Inflammatory Responses"
-	D.M. Smith, G. Gorgas, B. McEwen, G. Poynter, C. Parrish, A. Wong, J. Hock
-	4th Annual Meeting of the International Society for Stem Cell Research (ISSCR), 6/06
"Differentiation Potential and Cell Cycle Regulation of Ex Vivo Expanded Bone Marrow-Derived Stem and Progenitor Cells for use in Autologous Cell Therapy"
-	K.L. Goltry, C. Parrish, R.J. Pavlic, J.M. Hock
-	12th Annual Meeting of the International Society for Cellular Therapy (ISCT), 5/06
"Clinical Feasibility Study: The Use of Cultured Enriched Autologous Bone Marrow Cells to Treat Refractory Atrophic and Hypotrophic Non-Union Fractures"
-	C. Solano, L. Rodriguez, C. Torrico, J. Douville, J.M. Hock, R.D. Armstrong, J. Garcia, L. Orozco
-	12th Annual Meeting of the International Society for Cellular Therapy (ISCT), 5/06
"Maintaining Mixed Populations of Adult Stem Cells Enhances Osteogenic Potential"
-	K. Esterly, J. Lee, G. Poynter, C. Parrish, J.A. Rowley, J. Hock, K. Goltry
-	Society for Biomaterials Annual Meeting & Exposition (SFB), 4/06
"In Vitro Optimization of Clinical Formulations of Adult Stem Cells with Matrices for Bone Regeneration"
-	J.A. Rowley, K. Esterly, B. McEwen, B. Pavlic, K. Goltry, J. Hock
-	Society for Biomaterials Annual Meeting & Exposition (SFB), 4/06
"Clinical Feasibility Study: Adult Stem Cell Therapy for Adult Non-Unions"
-	M.L. Jimenez, MD, Illinois Bone & Joint Institute
-	Aastrom Biosciences, Inc. filed slides with the SEC on Form 8-K: 3/22/2006
"Culture Surfaces and Reduced Serum Influence Ex Vivo Production of Bone Marrow-Derived Osteoprogenitors"
-	M.R. Kreke, N. Henley, K.L. Goltry
-	52nd Annual Meeting of the Orthopaedic Research Society (ORS), 03/06
"Novel Perfusion Culture Process for Clinical-Scale Expansion of Melanoma Antigen-Reactive Tumor Infiltrating Lymphocytes (TILS) in a Closed Bioreactor System"
-	D.M. Smith, G.C. Gorgas, N.A. Venturi, C.R. Parrish, B.S. Hampson
-	Keystone Symposia, 1/06
"Hematopoietic Stem Cell Localization on a 3-D Matrix"
-	S. Snabes, L. Noll, D. Smith, L. Lasky, N. Kotov, E. Elliot, J. Lee, J. Hwan
-	45th Annual Meeting of the American Society for Cell Biology, 12/05
-	Aastrom Biosciences, Inc. report filed with the SEC on Form 8-K: 5/17/2005
"Flow Cytometric Characterization of Perfused Human Bone Marrow Cultures: Identification of the Major Cell Lineages and Correlation With the CFU-GM Assay"
-	D.A. Brott, R.J. Maher, C.R. Parrish, R.J. Richardson, A.K. Smith
-	Cytometry Part A, Vol. 53A: 22-27, 2003
"Augmentation of Umbilical Cord Blood (UCB) Transplantation With Ex Vivo-Expanded UCB Cells: Results of a Phase I Trial Using the AastromReplicell System"
-	J. Jaroscak, K. Goltry, A. Smith, B. Waters-Pick, P.L. Martin, T.A. Driscoll, R. Howrey, N. Chao, J. Douville, S. Burhop, P. Fu, J. Kurtzberg
-	Blood, Vol.101(12): 5061-5067, 2003
"Marrow Cell Transplantation for Infantile Hypophasphatasia"
-	M.P. Whyte, J. Kurtzberg, W.H. McAlister, S. Mumm, M.N. Podgornik, S.P. Coburn, L.M. Ryan, C.R. Miller, G.S. Gottesman, A.K. Smith, J. Douville, B. Waters-Pick, R.D. Armstrong, P.L. Martin
-	Journal of Bone and Mineral Research, Vol. 18 (4): 624-636, 2003
"A Phase II Trial Evaluating the Safety and Effectiveness of the AastromReplicell System for Augmentation of Low-Dose Blood Stem Cell Transplantation"
-	A.L. Pecora, P. Stiff, C.F. LeMaistre, R. Bayer, C. Banchier, S.L. Goldberg, M. Parthasarathy, A.A. Jennis, A.K. Smith, J. Douville, B. Chen, R.D. Armstrong, R.K. Mandalam, R. Preti
-	Bone Marrow Transplantation, Vol. 28: 295-303, 2001
"Hematopoietic Recovery of Ex Vivo Perfusion Culture Expanded Bone Marrow and Unexpanded Peripheral Blood Progenitors After Myeloablative Chemotherapy"
-	M. Englehardt, J. Douville, D. Behringer, A. Jähne, A. Smith, R. Henschler, W. Lange
-	Bone Marrow Transplantation, Vol. 27: 249-259, 2001
"Prompt and Durable Engraftment in Two Older Adult Patients with High Risk Chronic Myelogenous leukemia (CML) Using ex vivo Expanded and Unmanipulated Unrelated Umbilical Cord Blood"
-	A.L. Pecora, P. Stiff, A. Jennis, S. Goldberg, R. Rosenbluth, P. Price, K.L. Goltry, J. Douville R.D. Armstrong, A.K. Smith, R.A. Preti
-	Bone Marrow Transplantation, Vol. 25 (7): 797-799, 2000
"Autologous Transplantation of Ex Vivo Expanded Bone Marrow Cells Grown from Small Aliquots After High-Dose Chemotherapy for Breast Cancer"
-	P. Stiff, B. Chen, W. Franklin, D. Oldenberg, E. His, R. Bayer, E. Shpall, J. Douville, R. Mandalam, D. Malhotra, T. Muller, R. Douglas Armstrong, A.K. Smith
-	Blood, Vol. 95 (6): 2169-2174, 2000