Current Clinical Trial Publications & Abstracts:
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"Determination of the Fate and Contribution of Ex Vivo Expanded Human Bone Marrow Stem and Progenitor Cells for Bone Formation by 2.3ColGFP"
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D. Yin, Z. Wang, Q. Gao, R. Sundaresan, C. Parrish, Q. Yang, P.H. Krebsbach, A.C. Lichtler, D.W. Rowe, J. Hock, P. Liu
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Molecular Therapy, Published online 7/14/09, http://www.nature.com/mt/journal/vaop/ncurrent/abs/mt2009151a.html
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"Single-Pass, Closed-System Rapid Expansion of Lymphocyte Cultures for Adoptive Cell Therapy"
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J.A. Klapper, A.A. Thomasian, D.M. Smith, G.C. Gorgas, J.R. Wunderlich, F.O. Smith, B.S. Hampson, S.A. Rosenberg, M.E. Dudley
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Journal of Immunological Methods, Vol. 345(1-2): 90-99, 2009
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"Proteomic Characteristics of ex vivo-Enriched Adult Human Bone Marrow Mononuclear Cells in Continuous Perfusion Cultures"
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A.K. Prahalad, J.H. Hock
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Journal of Proteome Research, Vol. 8(4): 2079-2089, 2009
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"Large-Scale Production of Adult Stem Cells for Clinical Use"
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K. Goltry, B. Hampson, N. Venturi, R. Bartel
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Emerging Technology Platforms for Stem Cells, John Wiley & Sons, Inc., Chapter 9: 153-168, 2009
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"Manufacturing Patient-Specific Cell Therapy Products - An Overview and Case Study of Tissue Repair Cell Technology"
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B. Hampson, J. Rowley, N. Venturi
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BioProcess International, Vol. 6(8): 60-72, 2008
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"Tissue Repair Cells for the Treatment of Cardiovascular Diseases"
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K. Goltry, J. Rowley, M. Peters, E. Burchardt
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Advances in Molecular Medicine, Vol. 3(1): 5-13, 2007
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"Good Manufacturing Practice-Compliant Expansion of Marrow-Derived Stem and Progenitor Cells for Cell Therapy"
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M.H. Gastens, K. Goltry, W. Prohaska, D. Tschöpe, B. Stratmann, D. Lammers, S. Kirana, C. Götting, K. Kleesiek
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Cell Transplantation, Vol. 16(7): 685-696, 2007
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"High Dose Stem and Progenitor Cell Therapy for Refractory Long Bone Non-Unions: Final Results of a Multi-Center Phase I/II Clinical Study"
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M.L. Jimenez, T. Lyon, G. Nowinski, J. Balazsy, J.A. Goulet, J.M. Hock, T.A. Sferra
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Orthopaedic Trauma Association 23rd Annual Meeting (OTA), 10/07
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"Cellular Based Therapy for the Treatment of Osteonecrosis of the Femoral Head"
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M.R. Kreke, J.A. Rowley, K.L. Goltry, R.L. Bartel
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ARCO (Association Research Circulation Osseous) Annual Meeting, 10/07
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"Stem Cell-Based Therapy for the Treatment of Femoral Head Necrosis - First Clinical Experience"
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U. Nöth
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2nd Congress of the German Society for Stem Cell Research, 10/07
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"Autologous Tissue Repair Cells (TRCs) in the Treatment of Ischemia Induced Chronic Tissue Ulcers of Diabetic Foot Patients Without Option of Revascularization: Interim Results"
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B. Stratmann
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2nd Congress of the German Society for Stem Cell Research, 10/07
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"Accessory Cells Enhance Osteogenic Potential of Bone Marrow Derived Mesenchymal Cells"
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A. Pennington, J. Dennis, C. Parrish, J. Lee, K. Goltry
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MSC2007 o Adult Mesenchymal Stem Cells in Regenerative Medicine, 8/07
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"Clinical-Scale Expansion of a Mixed Population of Bone Marrow Derived Stem and Progenitor Cells for Potential Use in Bone Tissue Regeneration"
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J.E. Dennis, K. Esterly, A. Awadallah, C.R. Parrish, G.M. Poynter, K.L. Goltry
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Stem Cells, Vol 25(10): 2575-82, 10/07
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"Cell-Based Therapy for the Treatment of Femoral Head Necrosis" (Translated from: 'Zellbasierte Therapie der Femurkopfnekrose')
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U. Nöth, J. Reichert, S. Reppenhagen, A. Steinert, L. Rackwitz, J. Eulert, J. Beckmann, M. Tingart
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Der Orthopäde, Vol. 36(5): 466-471, 5/07
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"Enhancing the Osteogenic
Potential of Bone-Marrow Derived Progenitor Cells in Primary Culture"
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K.L. Goltry, J.J. Lee, C.R. Parrish
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28th Annual Meeting of the American Society for
Bone & Mineral Research (ASBMR), 9/06
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"Feasibility Clinical Trial:
Early Results Show Healing of Recalcitrant Non-Union Fractures Using
Autologous Tissue Repair Cells, a Bone Marrow-Derived Tissue Enriched
for Adult Stem and Progenitor Cells"
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M. Jimenez, T. Lyon, J. Balazsy, G. Nowinski,
J. Goulet, S. Wolff, J. Block, T. Sferra, R.D. Armstrong, J. Douville,
G. O'Brien, J.M. Hock
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28th Annual Meeting of the American Society
for Bone & Mineral Research (ASBMR), 9/06
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"Efficient Tracking of the
Fate of Human Bone Marrow Stem Cells for Bone Regeneration Using a
Bone-Specific Promoter Driving GFP Within a Lentiviral Vector"
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D. Yin, Z. Wang, Q. Gao, R. Sundaresan, C. Parrish,
P.H. Krebsbach, A. Lichtler, D.W. Rowe, J.M. Hock, P. Liu
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28th Annual Meeting of the American Society for
Bone & Mineral Research (ASBMR), 9/06
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"Adult Bone Marrow-Derived Cells
Cultured by Single Pass Perfusion Technology Induce Bony Spine Fusion in
Immunodeficient Rats"
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K.M. Esterly, E. Frankenburg, S. Oyserman, R. Pavlic,
C. Parrish, J. Kreider, J.M. Kreider, S. Goldstein
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4th Annual Meeting of the International Society for
Stem Cell Research (ISSCR), 6/06
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"Regulation of the Cell Cycle
During Ex Vivo Expansion of Bone Marrow-Derived Stem Cells for use in
Autologous Cell Therapy"
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K. Goltry, C. Parrish, B. Pavlic, J.M. Hock
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4th Annual Meeting of the International Society for
Stem Cell Research (ISSCR), 6/06
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"Ex Vivo Expanded Osteoprogenitor Cells: Mixed vs Purified Cell Populations for Bone Regeneration"
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M.R. Kreke, K.J. Whittlesey, J.J. Lee, G.M. Poynter,
C. Parrish, A. Awadallah, J.E. Dennis, K.L. Goltry
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4th Annual Meeting of the International Society for
Stem Cell Research (ISSCR), 6/06
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"Ex Vivo Expanded Bone Marrow-Derived Stem and Progenitor Cells Express a Cellular Composition and Molecular Profile with High Functionality for Tissue Repair in the Absence of Tissue Destructive Inflammatory Responses"
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D.M. Smith, G. Gorgas, B. McEwen, G. Poynter, C. Parrish, A. Wong, J. Hock
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4th Annual Meeting of the International Society for Stem
Cell Research (ISSCR), 6/06
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"Differentiation Potential
and Cell Cycle Regulation of Ex Vivo Expanded Bone Marrow-Derived Stem and
Progenitor Cells for use in Autologous Cell Therapy"
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K.L. Goltry, C. Parrish, R.J. Pavlic, J.M. Hock
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12th Annual Meeting of the International Society for
Cellular Therapy (ISCT), 5/06
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"Clinical Feasibility Study: The
Use of Cultured Enriched Autologous Bone Marrow Cells to Treat Refractory
Atrophic and Hypotrophic Non-Union Fractures"
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C. Solano, L. Rodriguez, C. Torrico, J. Douville,
J.M. Hock, R.D. Armstrong, J. Garcia, L. Orozco
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12th Annual Meeting of the International Society
for Cellular Therapy (ISCT), 5/06
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"Maintaining Mixed Populations
of Adult Stem Cells Enhances Osteogenic Potential"
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K. Esterly, J. Lee, G. Poynter, C. Parrish, J.A.
Rowley, J. Hock, K. Goltry
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Society for Biomaterials Annual Meeting &
Exposition (SFB), 4/06
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"In Vitro Optimization of
Clinical Formulations of Adult Stem Cells with Matrices for
Bone Regeneration"
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J.A. Rowley, K. Esterly, B. McEwen, B. Pavlic, K.
Goltry, J. Hock
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Society for Biomaterials Annual Meeting & Exposition
(SFB), 4/06
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"Clinical Feasibility Study:
Adult Stem Cell Therapy for Adult Non-Unions"
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M.L. Jimenez, MD, Illinois Bone & Joint
Institute
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Aastrom Biosciences, Inc. filed slides with the SEC
on Form 8-K: 3/22/2006
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"Culture Surfaces and Reduced
Serum Influence Ex Vivo Production of Bone Marrow-Derived
Osteoprogenitors"
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M.R. Kreke, N. Henley, K.L. Goltry
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52nd Annual Meeting of the Orthopaedic Research
Society (ORS), 03/06
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"Novel Perfusion Culture
Process for Clinical-Scale Expansion of Melanoma Antigen-Reactive Tumor
Infiltrating Lymphocytes (TILS) in a Closed Bioreactor System"
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D.M. Smith, G.C. Gorgas, N.A. Venturi, C.R. Parrish,
B.S. Hampson
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Keystone Symposia, 1/06
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"Hematopoietic Stem Cell
Localization on a 3-D Matrix"
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S. Snabes, L. Noll, D. Smith, L. Lasky, N. Kotov,
E. Elliot, J. Lee, J. Hwan
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45th Annual Meeting of the American Society for
Cell Biology, 12/05
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Aastrom Biosciences, Inc. report filed with
the SEC on Form 8-K: 5/17/2005
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"Flow Cytometric Characterization
of Perfused Human Bone Marrow Cultures: Identification of the Major Cell Lineages
and Correlation With the CFU-GM Assay"
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D.A. Brott, R.J. Maher, C.R. Parrish, R.J. Richardson,
A.K. Smith
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Cytometry Part A, Vol. 53A: 22-27, 2003
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"Augmentation of Umbilical Cord
Blood (UCB) Transplantation With Ex Vivo-Expanded UCB Cells: Results of a
Phase I Trial Using the AastromReplicell System"
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J. Jaroscak, K. Goltry, A. Smith, B. Waters-Pick,
P.L. Martin, T.A. Driscoll, R. Howrey, N. Chao, J. Douville, S. Burhop,
P. Fu, J. Kurtzberg
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Blood, Vol.101(12): 5061-5067, 2003
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"Marrow Cell Transplantation for
Infantile Hypophasphatasia"
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M.P. Whyte, J. Kurtzberg, W.H. McAlister, S. Mumm,
M.N. Podgornik, S.P. Coburn, L.M. Ryan, C.R. Miller, G.S. Gottesman, A.K.
Smith, J. Douville, B. Waters-Pick, R.D. Armstrong, P.L. Martin
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Journal of Bone and Mineral Research, Vol. 18
(4): 624-636, 2003
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"A Phase II Trial Evaluating the
Safety and Effectiveness of the AastromReplicell System for Augmentation of
Low-Dose Blood Stem Cell Transplantation"
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A.L. Pecora, P. Stiff, C.F. LeMaistre, R. Bayer,
C. Banchier, S.L. Goldberg, M. Parthasarathy, A.A. Jennis, A.K. Smith, J.
Douville, B. Chen, R.D. Armstrong, R.K. Mandalam, R. Preti
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Bone Marrow Transplantation, Vol. 28: 295-303,
2001
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"Hematopoietic Recovery of Ex
Vivo Perfusion Culture Expanded Bone Marrow and Unexpanded Peripheral Blood
Progenitors After Myeloablative Chemotherapy"
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M. Englehardt, J. Douville, D. Behringer, A. Jähne,
A. Smith, R. Henschler, W. Lange
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Bone Marrow Transplantation, Vol. 27: 249-259,
2001
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"Prompt and Durable Engraftment
in Two Older Adult Patients with High Risk Chronic Myelogenous leukemia
(CML) Using ex vivo Expanded and Unmanipulated Unrelated Umbilical
Cord Blood"
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A.L. Pecora, P. Stiff, A. Jennis, S. Goldberg, R.
Rosenbluth, P. Price, K.L. Goltry, J. Douville R.D. Armstrong, A.K. Smith,
R.A. Preti
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Bone Marrow Transplantation, Vol. 25 (7): 797-799,
2000
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"Autologous Transplantation of
Ex Vivo Expanded Bone Marrow Cells Grown from Small Aliquots After
High-Dose Chemotherapy for Breast Cancer"
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P. Stiff, B. Chen, W. Franklin, D. Oldenberg, E. His,
R. Bayer, E. Shpall, J. Douville, R. Mandalam, D. Malhotra, T. Muller, R.
Douglas Armstrong, A.K. Smith
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Blood, Vol. 95 (6): 2169-2174, 2000
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